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while there is no cure for these conditions, treatment to alleviate symptoms, suppress recurrences and reduce transmission has improved over the past 20 years with the use of guanine nucleoside antivirals, such as valacyclovir hydrochloride valtrex , glaxosmithkline the highly bioavailable prodrug of acyclovir zovirax, glaxosmithkline , and famciclovir famvir, novartis , a highly bioavailable prodrug of penciclovir denavir, novartis .