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In a multicenter, double-blind, 24-week trial, 214 patients with type 2 diabetes mellitus treated with thiazolidinediones rosiglitazone or pioglitazone for a minimum of 3 months and simvastatin 20 mg for a minimum of 6 weeks were randomized to receive either simvastatin 40 mg or the coadministered active ingredients equivalent to vytorin 10 20.
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the results of a bioequivalence study in healthy subjects demonstrated that the vytorin ezetimibe and simvastatin 10 mg 10 mg to 10 mg 80 mg combination tablets are bioequivalent to coadministration of corresponding doses of ezetimibe zetia and simvastatin zocor as individual tablets.
